Breast cancer
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Breast cancer, symptoms and risk factors.
Breast cancer is the most common cancer in women with over 60,000 new cases each year. It is important to understand and highlight the symptoms and risk factors associated with this cancer in order to put in place more effective prevention, early detection and treatment strategies.

Better understanding triple negative breast cancer.
Among all breast cancers, one in particular is getting a lot of attention: triple-negative breast cancer. It is characterized by an absence of expression of three receptors: estrogen receptors (ER), progesterone receptors (PR), and HER2 receptors.

What biomarkers and genetic mutations are involved in breast cancer?
Understanding the molecular aspects of breast cancer and knowing the biomarkers and genetic mutations associated with this pathology is essential for the therapeutic orientation of patients. It also makes it possible to improve clinical research with the development of more targeted and effective treatments.
Frequently asked questions
What are the histologies (subtypes) of breast cancer?
Histology is the set of characteristics of cancerous tissue, determined under the microscope by anatomopathological examine.This information can be found on the anatomopathological report or on a consultation report.It is essential to indicate histology among the proposed list because some may allow access to clinical trials and targeted medicines.There are several histological subtypes:
- Ductal carcinoma in situ (DCIS)
- Invasive ductal carcinoma
- Lobular carcinoma in situ (CLIS)
- Invasive lobular carcinoma...
(complete list on the Klineo platform)
What is the TNM breast cancer score?
The TNM score is a classification system used to assess the stage of a cancer, plan treatment, and predict prognosis.
The TNM system is based on three main criteria:
- The T, which describes the size and extent of the tumor.
- The N, which indicates whether the cancer has spread to nearby lymph nodes.
- The M, which indicates whether the cancer has spread to other parts of the body, called metastases.
(see table below)
This information can be found on the pathologic report or a consultation report.
NB: On the platform it is a simplified version of the TNM stadium. In the search fields, only the first number following the letter must be selected (ex: “Pt1c N0i+ M0” = “T1N0M0”)
TNM breast cancer classification chart
| Tumour (T) | Description |
|---|---|
| T0 | No tumour |
| T1 | < 2 cm |
| T2 | > 2 cm and < 5 cm |
| T3 | > 5 cm |
| T4a | deep involvement |
| T4b | superficial involvement |
| T4c | T4a + T4b |
| T4di | inflammatory signs |
| Nodes (N) | Description |
|---|---|
| N0 | No regional lymph node involvement |
| N1 | Suspicious but mobile ipsilateral axillary lymph nodes |
| N2 | Ipsilateral axillary lymph nodes fixed to each other or to other structures |
| N3 | Ipsilateral internal mammary lymph nodes |
| Metastases (M) | Description |
|---|---|
| M0 | No distant metastasis |
| M1 | Presence of distant metastases (including supraclavicular lymph node metastases) |
| Mx | Assessment pending |
What is the stage of breast cancer?
The stage of breast cancer is based on a correspondence to the TNM score (see above), which is a system used to describe the extent of cancer spread. There are 5 different stages (0 to IV). The correspondence table below summarizes the different stages according to the TNM score.
It is essential to indicate the stage in order to access clinical trials and targeted drugs. This information can be found on the pathologic report or a consultation report.
| Stage | Tumour (T) | Nodes (N) | Metastases (M) |
|---|---|---|---|
| 0 | Tis | N0 | M0 |
| I | T1 | N0 | M0 |
| IIA | T0 | N1 | M0 |
| IIA | T1 | N1 | M0 |
| IIA | T2 | N0 | M0 |
| IIB | T2 | N1 | M0 |
| IIB | T3 | N0 | M0 |
| IIIA | T0 | N2 | M0 |
| IIIA | T1 | N2 | M0 |
| IIIA | T2 | N2 | M0 |
| IIIA | T3 | N1 | M0 |
| IIIA | T3 | N2 | M0 |
| IIIB | T4 | N0 | M0 |
| IIIB | T4 | N1 | M0 |
| IIIB | T4 | N2 | M0 |
| IIIC | Any T | N3 | M1 |
| IV | Any T | Any N | M1 |
Patient associations

Collectif Triplettes Roses
Taking action for women with triple negative breast cancer
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